Correlation between specific gene, MS in Iranians confirmed

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Tehran (ISNA) - A new study published in Avicenna Journal of Medical Biotechnology, affiliated to Jahad Daneshgahi, explores the relation between a particular polymorphic gene and Multiple sclerosis (MS).

Multiple sclerosis is a demyelinating disease in which the insulating covers of nerve cells in brain and spinal cord are damaged. This damage, in turn, disrupts the ability of parts of the nervous system to communicate, resulting in a range of signs and symptoms including physical, mental, and sometimes psychiatric problems.

Scientists at Isfahan University of Medical Sciences have recently investigated a protein dubbed AIRE and the role of this polymorphic genotype in the emergence or prevention of MS.

AIRE acts as a strong transcription activator and if absent in the body, individuals might develop autoimmune diseases in multiple organs because of defect in their thymus gland.

In a special interview with SinaPress, Fereshteh Saheb Fosoul, PhD, said, “This is one of the genes that regulate the immune system and it is polymorphic; we examined its relation to Multiple sclerosis.”

In the study, 112 patients with MS, including 87 females and 25 males, all visiting MS Center at Alzahra Hospital in Isfahan, were investigated. Also, 94 healthy subjects were in the control group for comparative tests.

The results show that the quantity of AIRE SNP rs1800520 in patients with MS was far less than in those in the control group.

This is the first study on the correlation between the polymorphic AIRE and MS.

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